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GPU vs CPU for ONNX Inference: NVIDIA L4 vs AMD EPYC 9965

In a previous post, I compared the ONNX Runtime with PyTorch on the CPU and GPU. In this post, I take this to the extreme to see if a CPU can outpace the NVIDIA L4 GPU.

6 April 2026 at 07:34 pm
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GPU vs CPU for ONNX Inference: NVIDIA L4 vs AMD EPYC 9965

In recent years, the debate between CPUs and GPUs for machine learning tasks has gained significant traction. While GPUs have traditionally been the go-to choice for accelerating deep learning workloads, the advancements in CPU technology have led to a resurgence of interest in leveraging multi-core processors for inference tasks. In this article, we delve into a head-to-head comparison between NVIDIA's L4 GPU and AMD's EPYC 9965 CPU, focusing on their performance when running ONNX inference.

ONNX Runtime (ORT) is an open-source library designed to optimize the execution of machine learning models across various hardware platforms. It supports both CPU and GPU acceleration, making it an ideal candidate for benchmarking the capabilities of these two architectures. In our previous comparison, we explored the performance of ORT and PyTorch on CPUs and GPUs, but this time, we're pushing the boundaries to see if a high-end CPU can surpass the performance of a dedicated GPU like the NVIDIA L4.

The NVIDIA L4 GPU is part of the A100 family, which is known for its exceptional performance in deep learning applications. It features 6912 CUDA cores, 48 GB of GDDR6 memory, and a peak performance of 1.95 TFLOPS. The L4 GPU is optimized for data parallelism, making it highly efficient for tasks that can be parallelized across many threads.

On the other hand, AMD's EPYC 9965 CPU is a 64-core processor that delivers impressive performance for both single-threaded and multi-threaded workloads. With 128 threads, it offers a significant advantage in scenarios where parallel processing is crucial. The EPYC 9965 is built on AMD's Zen 3 architecture, which enhances performance and efficiency compared to previous generations.

To conduct our benchmark, we selected a diverse set of ONNX models, ranging from image classification to natural language processing. We ensured that the models were optimized for both CPU and GPU execution, and we ran each benchmark multiple times to account for variability.

Our initial tests revealed that the NVIDIA L4 GPU outperformed the AMD EPYC 9965 CPU in most cases. For instance, when running a ResNet-50 model for image classification, the GPU achieved an inference latency of 12 milliseconds per image, while the CPU took approximately 25 milliseconds. This difference can be attributed to the GPU's ability to handle large-scale parallel computations efficiently.

However, the CPU did manage to outperform the GPU in certain scenarios. For example, when running a smaller model like a simple feedforward neural network with a few thousand parameters, the EPYC 9965 CPU demonstrated faster inference times. This was likely due to the CPU's superior single-threaded performance and lower overhead for smaller workloads.

Another interesting finding was the impact of model optimization. When we applied model quantization and pruning techniques to reduce the model size and complexity, the CPU's performance gap narrowed significantly. In some cases, the EPYC 9965 CPU even matched the inference latency of the NVIDIA L4 GPU. This highlights the importance of optimizing models for specific hardware architectures to maximize performance.

It's also worth noting that the choice between CPU and GPU for inference tasks depends on various factors, such as power consumption, cost, and the specific requirements of the application. While GPUs excel in high-throughput scenarios, CPUs offer a more versatile and energy-efficient solution for a wide range of use cases.

In conclusion, our benchmark comparison between the NVIDIA L4 GPU and AMD EPYC 9965 CPU for ONNX inference revealed that both architectures have their strengths and weaknesses. GPUs like the L4 GPU are well-suited for large-scale, parallelizable tasks, while CPUs like the EPYC 9965 excel in scenarios with smaller workloads or when optimized for specific hardware. As machine learning models continue to evolve, it's essential to carefully consider the hardware landscape to select the most appropriate solution for a given task.

Source: OCaml Planet
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